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Historical records indicate that extensive cultural, commercial and technological interaction occurred between European and Asian populations.

Homo sapiens subsequently proceeded to populate the entire continent during the Mesolithic and advanced north, following the retreating ice sheets of the last glacial maximum.

We systematically estimated gene flow between Eurasian groups using genome-wide polymorphisms from 34 populations representing Europeans, East Asians, and Central/South Asians.

We identified recent gene flow between Europeans and Asians in most populations we studied, including East Asians and Northwestern Europeans, which are normally considered to be non-admixed populations.

The interaction between European and Asian populations has been historically influenced by many factors, including the political conditions created by great empires such as the Roman (31 BC–250 AD) and Mongolian empires (1207 AD–1360 AD) that fostered communication between European and Asian populations, and the famous Silk Road (206 BC) which acted historically as a commercial, religious, and cultural network interlinking the trade routes across the Eurasian landmass that connected East Asia with the Mediterranean and Europe.

This raises the question of whether genetic admixture occurred during the interaction between people from different regions, particularly between Europe and East Asia.

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